♦ Kinship index calculation

When perfectly matching between two haplotypes, kinship index (KI) can be calculated from haplotype frequency.

In non-matching cases due to mutation, Rolf et al. (ref. 1) presented calculation method of KI with average value of mutation rates of Y-STR loci.

However, this method is limited to reflect different effect of mutations of Y-STR loci, because of usage of the average mutation rate.

Therefore, ySTRmanager uses loci-specific muatation rates in KI calculatoin instead of the average value to provide more exact KI value and to reflect different effect of mutation for each locus.



ySTRmanager provided KI calculation function for only single-step mutation (+1 repeat gain or -1 repeat loss) in each locus based on stepwise mutation model.


Reference

1. Rolf B, Keil W, Brinkmann B, Roewer L, Fimmers R. Paternity testing using Y-STR haplotypes: assigning a probability for paternity in cases of mutations. Int J Legal Med 2001;115(1):12-5.
2. Buckleton JS, Triggs CM, Walsh SJ. Forensic DNA evidence interpretation. 1st ed. Boca Raton: CRC press; 2005. p. 388-389.