1. Introduction
• Y-STR haplotyping of male DNA is a powerful tool for identifying paternal lineage in both forensic and genealogical case work, 
  and in anthropological and evolutionary studies.
• In practice, between nine and 17 Y-STRs are used for haplotyping, which normally provides enough information for reliable lineage identification.
• ySTRmanager is a database system for managing Y-STR data, which provides three functions for Y-STR haplotype search,
  kinship index calculation, and user database configuration.

2. Three functions of ySTRmanager
• Y-STR haplotype search using database system
  (1) Basically, a haplotype provided manually can be searched in open database to obtain haplotype frequency without membership login.
  (2) Registered users are able to use totally 4 types of searches with combinations of two search targets (open or user DBs) 
       and two types of input queries (by inputting directly or selecting a data in stored user DB).
  (3) Three types of results will be displayed at the bottom of search options.
       - Summary of search results that comprise number of matches and haplotype frequency obtained from selected population
       - List of matched haplotypes that are sorted by number of haplotypes in descending order
       - List of neighbor haplotypes including single-step mutations that are sorted by Y-STR locus-specific mutation rates in descending order

• Kinship index calculation using Y-STR loci-specific mutation rates
  (1) Kinship index (KI) and kinship probability can be calculated from two haplotypes of male relatives (e.g., father-son pair)
       when a single-step mutation is observed in a locus as a difference between the haplotypes.
  (2) To obtain more accurate KI value, Y-STR locus specific mutation rates are used instead of average value of them.
       - Previously published worldwide mutation rates are basically provided to calculate kinship index.
       - Registered users are able to store their own mutation data into ySTRmanager and to use the data for this calculation function.

• User database configuration
  (1) ySTRmanager supports storage and management of Y-STR data and mutation data.
  (2) Stored user's Y-STR data can be used as input queries to estimate their frequencies in selected population.
       Moreover, each group of user's Y-STR data can be used as a search target.
  (3) User's mutation data can also be used in kinship data calculation.

3. The ySTRmanager was developed by:
In Seok Yang1, Hwan Young Lee1,2, Myung Jin Park1, Woo Ick Yang1, Kyoung-Jin Shin1,2
    1Department of Forensic Medicine, Yonsei University College of Medicine, Seoul, Korea
    2Human Identification Research Center, Yonsei University, Seoul Korea

(2) Publication in the Korean J Legal Med 2012;36:45-55.

(1) Oral presentation at the 17th Spring Meeting of the Korean Society for Legal Medicine. Gwangju, Korea. May 25, 2012.

4. Contact us
For comments, bug reports, suggestions for improvement, please contact through e-mail: kjshin@yuhs.ac.
When reporting a bug or any apparent malfunction, please try to include as much information as possible about the problem.
In many cases, the data used help a lot too.

About us, please visit Yonsei DNA Profiling Group.
Yonsei DNA Profiling Group
Department of Forensic Medicine, Yonsei University College of Medicine
50 Yonsei-ro, Seodaemun-gu, Seoul, 120-752, Korea