• Y-STR haplotyping of male DNA is a powerful tool for identifying paternal lineage in both forensic and genealogical case work, 
  and in anthropological and evolutionary studies.
• In practice, between nine and 17 Y-STRs are used for haplotyping, which normally provides enough information for reliable lineage identification.
• ySTRmanager is a database system for managing Y-STR data, which provides three functions for Y-STR haplotype search,
  kinship index calculation, and user database configuration.

• Y-STR haplotype search using database system
  (1) Basically, a haplotype provided manually can be searched in open database to obtain haplotype frequency without membership login.
  (2) Registered users are able to use totally 4 types of searches with combinations of two search targets (open or user DBs) 
       and two types of input queries (by inputting directly or selecting a data in stored user DB).
  (3) Three types of results will be displayed at the bottom of search options.
       - Summary of search results that comprise number of matches and haplotype frequency obtained from selected population
       - List of matched haplotypes that are sorted by number of haplotypes in descending order
       - List of neighbor haplotypes including single-step mutations that are sorted by Y-STR locus-specific mutation rates in descending order

• Kinship index calculation using Y-STR loci-specific mutation rates
  (1) Kinship index (KI) and kinship probability can be calculated from two haplotypes of male relatives (e.g., father-son pair)
       when a single-step mutation is observed in a locus as a difference between the haplotypes.
  (2) To obtain more accurate KI value, Y-STR locus specific mutation rates are used instead of average value of them.
       - Previously published worldwide mutation rates are basically provided to calculate kinship index.
       - Registered users are able to store their own mutation data into ySTRmanager and to use the data for this calculation function.

• User database configuration
  (1) ySTRmanager supports storage and management of Y-STR data and mutation data.
  (2) Stored user's Y-STR data can be used as input queries to estimate their frequencies in selected population.
       Moreover, each group of user's Y-STR data can be used as a search target.
  (3) User's mutation data can also be used in kinship data calculation.

In Seok Yang1, Hwan Young Lee1,2, Myung Jin Park1, Woo Ick Yang1, Kyoung-Jin Shin1,2
    1Department of Forensic Medicine, Yonsei University College of Medicine, Seoul, Korea
    2Human Identification Research Center, Yonsei University, Seoul Korea

(2) Publication in the Korean J Legal Med 2012;36:45-55.

(1) Oral presentation at the 17th Spring Meeting of the Korean Society for Legal Medicine. Gwangju, Korea. May 25, 2012.

For comments, bug reports, suggestions for improvement, please contact through e-mail: kjshin@yuhs.ac.
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In many cases, the data used help a lot too.

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